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In adult rodent glia, the NFkappaB transcription factor is activated during immune responses, stress, and numerous cell death-inducing factors;however, in glioma cells, this transcription factor is constitutively active and required for invasion.
Roles for NFkappaB in glioma formation and progression remain to be fully elucidated. The goal of this proposal is to characterize glioma cells for a role for NFkappaB in growth and survival, and to identify potential molecular targets of the pathway. The research will test the hypothesis that NFkappaB is activated by growth factors and mitogens in glioma cells and required for the proliferation and survival of these cells, and ultimately for the formation of aggressive tumors.
First, molecular mechanisms of NFkappaB activation will be examined. The regulation of NFkappaB will be analyzed at the levels of protein stability and nuclear translocation. Y-Force Download J-Force for free and see how the new product navigation tool makes it посмотреть еще than ever to autoodesk what you’re looking for.
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